Description

2-(Trifluoromethyl)-3-Azabicyclo[3.1.0]Hexane is a specialized, high-value bicyclic amine building block featuring a trifluoromethyl group. This compound is a critical intermediate in modern pharmaceutical and agrochemical research, where its unique three-dimensional structure and fluorine substitution are leveraged to modulate the biological activity, metabolic stability, and physicochemical properties of target molecules. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of central nervous system (CNS) drugs, enzyme inhibitors, and other bioactive molecules.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the CF3 group enhances lipophilicity and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers and advanced materials requiring fluorine-containing moieties.
• Medicinal Chemistry Scaffold: Provides a rigid, sp3-rich bicyclic framework for constructing compound libraries in drug discovery programs.
• Fluorine Chemistry: An important reagent for introducing the trifluoromethylated azabicyclo[3.1.0]hexane motif into complex molecular architectures.

Basic Information

Product Name	2-(Trifluoromethyl)-3-Azabicyclo[3.1.0]Hexane
CAS No.	1212082-75-1
Molecular Formula	C7H10F3N
Molecular Weight	165.16 g/mol
Synonyms	2-(Trifluoromethyl)-3-azabicyclo[3.1.0]hexane; 3-Azabicyclo[3.1.0]hexane, 2-(trifluoromethyl)-; 2-Trifluoromethyl-3-azabicyclo[3.1.0]hexane; 2-(Trifluoromethyl)-3-azabicyclo[3.1.0]hexane hydrochloride (salt form); 2-CF3-3-azabicyclo[3.1.0]hexane; Bicyclo[3.1.0]hexane, 2-(trifluoromethyl)-3-aza-; Trifluoromethyl azabicyclohexane; 1212082-75-1
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)-3-Azabicyclo[3.1.0]Hexane is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA), including results from NMR, HPLC, and GC analysis, is supplied with each shipment to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid or clear colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.