Description

5-Fluoromethylene-4-Phenyl-5H-Furan-2-One is a specialized fluorinated furanone derivative, a high-value building block in advanced organic synthesis. Its unique structure, featuring a fluoromethylene group, makes it a critical intermediate for developing novel pharmaceuticals and agrochemicals with enhanced biological activity and metabolic stability. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atom improves lipophilicity, bioavailability, and environmental persistence.
• Material Science Research: Serves as a precursor for novel fluorinated polymers, liquid crystals, or organic electronic materials with specific optical or electronic properties.
• Chemical Biology Probes: Employed in the design of fluorinated probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Fluoromethylene-4-Phenyl-5H-Furan-2-One
CAS No.	1212059-19-2
Molecular Formula	C11H7FO2
Molecular Weight	190.17 g/mol
Synonyms	5-(Fluoromethylene)-4-phenyl-2(5H)-furanone; 4-Phenyl-5-(fluoromethylene)-5H-furan-2-one; 5-Fluoromethylene-4-phenylfuran-2(5H)-one; 2(5H)-Furanone, 5-(fluoromethylene)-4-phenyl-; 5-Fluoromethylene-4-phenyl-2,5-dihydrofuran-2-one
EINECS	Contact for details

Quality Control

Our 5-Fluoromethylene-4-Phenyl-5H-Furan-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.