Description

3-Bromo-4-Trifluoromethylbenzonitrile is a high-value, multi-functional aromatic nitrile building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for facilitating advanced molecular construction in pharmaceutical and agrochemical research, offering versatile reactivity for cross-coupling and functional group transformations. It is primarily sought after by R&D chemists and process development scientists in the life sciences and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and polymers where specific halogenated and fluorinated aromatics are required.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form complex biaryl systems.
• Chemical Biology Probes: Utilized as a building block for synthesizing molecular probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	3-Bromo-4-Trifluoromethylbenzonitrile
CAS No.	1212021-55-0
Molecular Formula	C8H3BrF3N
Molecular Weight	250.02 g/mol
Synonyms	4-Cyano-2-bromobenzotrifluoride; 2-Bromo-α,α,α-trifluoro-p-tolunitrile; Benzonitrile, 3-bromo-4-(trifluoromethyl)-; 3-Bromo-4-(trifluoromethyl)benzonitrile; p-Cyanobenzotrifluoride, 2-bromo-; 2-Bromo-4-cyanobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Trifluoromethylbenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as verified by HPLC, GC, NMR, and IR spectroscopy. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.