Description

4-Iodo-6-Methylnicotinonitrile is a halogenated pyridine derivative that serves as a versatile and valuable building block in advanced organic synthesis. Its molecular structure, featuring both an iodine substituent and a nitrile group, makes it a critical intermediate for constructing complex heterocyclic systems and functionalized molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, cross-coupling reactions, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in constructing pharmacologically active pyridine cores.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides that require halogenated heterocyclic structures.
• Material Science Research: Serves as a precursor for the synthesis of specialized ligands, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings to form carbon-carbon bonds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A high-purity starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	4-Iodo-6-Methylnicotinonitrile
CAS No.	1211594-67-0
Molecular Formula	C7H5IN2
Molecular Weight	244.03 g/mol
Synonyms	6-Methyl-4-iodonicotinonitrile; 4-Iodo-6-methyl-3-pyridinecarbonitrile; 3-Cyano-4-iodo-6-methylpyridine; 4-Iodo-6-methylpyridine-3-carbonitrile; Nicotinonitrile, 4-iodo-6-methyl-; 1211594-67-0; 4-Iodo-6-methyl-3-cyanopyridine
EINECS	Contact for details

Quality Control

Every batch of 4-Iodo-6-Methylnicotinonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development applications. A detailed Certificate of Analysis (COA), confirming identity, purity, and impurity profiles via techniques such as HPLC, NMR, and mass spectrometry, is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.