Description

2-Ethynylpyridine-5-Carbonitrile is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both an ethynyl and a nitrile group, makes it an invaluable precursor for constructing complex heterocyclic systems and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, ligand synthesis, and polymer development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators that require pyridine-based scaffolds.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of advanced organic electronic materials, conductive polymers, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological processes and target engagement.
• Heterocyclic Chemistry: A fundamental starting material for constructing complex nitrogen-containing heterocycles via cycloaddition and cross-coupling reactions.

Basic Information

Product Name	2-Ethynylpyridine-5-Carbonitrile
CAS No.	1211588-35-0
Molecular Formula	C8H4N2
Molecular Weight	128.13 g/mol
Synonyms	5-Cyano-2-ethynylpyridine; 2-Ethynyl-5-cyanopyridine; 2-Ethynylpyridine-5-carbonitrile; Pyridine, 5-cyano-2-ethynyl-; 5-Cyano-2-ethynylpyridine; 2-(Ethynyl)-5-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 2-Ethynylpyridine-5-Carbonitrile is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by modern analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.