Description

1-Bromo-2-Ethynyl-4-Trifluoromethylbenzene is a high-value, multi-functional aromatic building block featuring bromine, ethynyl, and trifluoromethyl substituents. This compound is engineered for advanced synthetic chemistry, offering versatile reactivity for cross-coupling and cycloaddition reactions. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-purity intermediates for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its conjugated ethynyl group and halogen functionality.
• Chemical Research: Employed in palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Suzuki) and click chemistry applications as a versatile aromatic scaffold.
• Fluorine Chemistry: A valuable reagent for introducing the trifluoromethylphenyl moiety into target molecules to modulate lipophilicity, metabolic stability, and binding affinity.

Basic Information

Product Name	1-Bromo-2-Ethynyl-4-Trifluoromethylbenzene
CAS No.	1211523-00-0
Molecular Formula	C9H4BrF3
Molecular Weight	249.03 g/mol
Synonyms	2-Bromo-1-ethynyl-4-(trifluoromethyl)benzene; 1-Ethynyl-2-bromo-4-(trifluoromethyl)benzene; 2-Ethynyl-1-bromo-4-trifluoromethylbenzene; (2-Bromo-4-(trifluoromethyl)phenyl)acetylene; 4-Trifluoromethyl-2-bromophenylacetylene; Benzene, 1-bromo-2-ethynyl-4-(trifluoromethyl)-; 2-Bromo-4-trifluoromethylphenylacetylene
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-2-Ethynyl-4-Trifluoromethylbenzene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available with each shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.