Description

3-(Pentafluorosulfur)Benzenesulfonyl Chloride is a high-value organosulfur and organofluorine building block characterized by its unique pentafluorosulfur (SF5) and reactive sulfonyl chloride functional groups. This compound is essential for introducing the highly electronegative, lipophilic, and thermally stable SF5 moiety into target molecules, significantly altering their physical and biological properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, as well as in advanced materials science for creating specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases where the SF5 group can enhance metabolic stability and binding affinity.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the SF5 group contributes to improved weatherfastness and pest selectivity.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, coatings, and liquid crystals with enhanced chemical resistance, thermal stability, and unique optical properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling proteins or modifying biomolecules due to the electrophilic nature of the sulfonyl chloride group.
• Ligand & Catalyst Development: Utilized to create novel ligands for catalysis or metal-organic frameworks (MOFs), leveraging the strong electron-withdrawing character of the SF5 substituent.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(Pentafluorosulfur)Benzenesulfonyl Chloride
CAS No.	1211520-62-5
Molecular Formula	C6H4ClF5O2S2
Molecular Weight	294.67 g/mol
Synonyms	3-(Pentafluoro-λ6-sulfanyl)benzenesulfonyl chloride; 3-SF5-Benzenesulfonyl chloride; m-SF5-Benzenesulfonyl chloride; Benzenesulfonyl chloride, 3-(pentafluorosulfur)-; 1-(Chlorosulfonyl)-3-(pentafluoro-λ6-sulfanyl)benzene; 3-(SF5)Phenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-(Pentafluorosulfur)Benzenesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, which is critical for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to support regulatory filings for our customers in advanced R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.