Description

3-Ethynyl-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block characterized by its ethynyl and trifluoromethyl substituents. This compound is essential for advanced research and development, enabling the synthesis of complex molecules with tailored electronic and steric properties. It is primarily sought by pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, ligand design, and the creation of novel functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and electronic materials due to its rigid, conjugated structure.
• Chemical Biology Probes: Utilized in click chemistry applications via its terminal alkyne group for bioconjugation and labeling studies.

Basic Information

Product Name	3-Ethynyl-5-(Trifluoromethyl)Pyridine
CAS No.	1211520-56-7
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	5-(Trifluoromethyl)-3-ethynylpyridine; 3-Ethynyl-5-(trifluoromethyl)pyridine; 3-Ethynyl-α,α,α-trifluoro-5-pyridinemethanol (tautomer); Pyridine, 3-ethynyl-5-(trifluoromethyl)-; 1211520-56-7
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.