Description

5-Bromo-2-(trifluoromethoxyl)benzonitrile is a high-value, multi-functional aromatic building block characterized by its bromine and trifluoromethoxy substituents. This compound is essential for advanced organic synthesis, offering a unique combination of reactivity and lipophilicity that is critical for developing novel chemical entities. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the trifluoromethoxy group into bioactive molecules.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the bromine atom allows for further functionalization.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine-containing groups on molecular properties in medicinal and materials chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for bespoke synthesis projects requiring specific halogenated aromatic nitriles.

Basic Information

Product Name	5-Bromo-2-(trifluoromethoxyl)benzonitrile
CAS No.	1210906-15-2
Molecular Formula	C8H3BrF3NO
Molecular Weight	266.02 g/mol
Synonyms	2-Bromo-5-(trifluoromethoxy)benzonitrile; 5-Bromo-2-(trifluoromethoxy)benzonitrile; 2-Bromo-α,α,α-trifluoro-p-anisonitrile; Benzonitrile, 5-bromo-2-(trifluoromethoxy)-; 1210906-15-2
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-2-(trifluoromethoxyl)benzonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and quantify impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with global regulatory frameworks, and custom purity grades (e.g., >97%, >98%, >99%) are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.