Description

2-Bromo-1,4-Difluoro-3-Methoxybenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecular architectures where precise electronic and steric control is required. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where the bromine and fluorine atoms contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, enhancing the performance and stability of display and lighting technologies.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the rapid diversification of chemical space in discovery libraries.
• Ligand & Catalyst Development: Employed in the synthesis of specialized phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.
• Chemical Research & Development: A versatile reagent for method development and exploring new reaction pathways in academic and industrial R&D settings.

Basic Information

Product Name	2-Bromo-1,4-Difluoro-3-Methoxybenzene
CAS No.	1208076-11-2
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	1-Bromo-2,5-Difluoro-4-Methoxybenzene; 3-Methoxy-2,5-Difluorobromobenzene; 2-Bromo-3-Methoxy-1,4-Difluorobenzene; Benzene, 2-bromo-1,4-difluoro-3-methoxy-; 1208076-11-2; 2,5-Difluoro-4-methoxybromobenzene; 4-Bromo-2,5-Difluoroanisole
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-1,4-Difluoro-3-Methoxybenzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency to meet the rigorous demands of process chemistry and scale-up. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.