Description

Dbco-(Ch2)3-Acid CAS NO 1207355-31-4 is a bifunctional linker molecule featuring a strained alkyne (DBCO) for bioorthogonal click chemistry and a carboxylic acid group for further conjugation. This compound is essential for researchers and manufacturers requiring efficient, catalyst-free labeling and crosslinking of biomolecules, such as antibodies, peptides, and oligonucleotides. It is a critical reagent for professionals in bioconjugation, pharmaceutical development, and diagnostic assay manufacturing, enabling the creation of targeted drug delivery systems and advanced bioanalytical tools.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic drugs, fluorophores, or other payloads to antibodies and proteins.
• Diagnostic Probe Synthesis: Labeling of oligonucleotides, peptides, or proteins for use in fluorescence in situ hybridization (FISH), immunoassays, and biosensors.
• Polymer and Material Science Functionalization: Modification of surfaces, nanoparticles, or hydrogels with bioactive ligands for cell culture or targeted delivery applications.
• Chemical Biology and Proteomics: As a key reagent for labeling and enriching azide-tagged biomolecules in live cells or complex biological samples.
• Pre-targeting Strategies in Radioimmunotherapy: Facilitating multi-step targeting approaches for improved tumor imaging and therapy.
• Crosslinking Agent: Creating stable covalent linkages between different molecules or materials under mild, physiological conditions.

Basic Information

Item	Detail
Product Name	Dbco-(Ch2)3-Acid
CAS No.	1207355-31-4
Molecular Formula	C19H21N3O3
Molecular Weight	339.39 g/mol
Synonyms	DBCO-PEG3-acid; DBCO-PEG3-COOH; Dibenzocyclooctyne-PEG3-acid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2,5,8,11-tetraoxatetradecan-14-oate); 3-[2-[2-[2-[[(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl]methoxy]ethoxy]ethoxy]ethoxy]propanoic Acid; Azadibenzocyclooctyne-PEG3-acid; ADIBO-PEG3-acid
EINECS	Contact for details

Quality Control

Our Dbco-(Ch2)3-Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.