Description

4-Trifluoromethoxypiperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is valued for its unique trifluoromethoxy-substituted piperidine structure, which is critical for modulating the physicochemical and metabolic properties of active pharmaceutical ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drugs.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Chemical Synthesis: Serves as a versatile precursor for introducing the trifluoromethoxypiperidine moiety into more complex molecular architectures in medicinal chemistry.
• Life Science Research: Employed in academic and industrial R&D for probing structure-activity relationships (SAR) and developing new chemical entities.
• Material Science: Potential use as a specialty monomer or additive in the development of advanced polymers with specific properties.

Basic Information

Product Name	4-Trifluoromethoxypiperidine Hydrochloride
CAS No.	1206984-05-5
Molecular Formula	C7H13ClF3NO
Molecular Weight	219.63 g/mol
Synonyms	4-(Trifluoromethoxy)piperidine hydrochloride; 1-(Trifluoromethoxy)piperidin-4-yl hydrochloride; Piperidine, 4-(trifluoromethoxy)-, hydrochloride; 4-Trifluoromethoxypiperidine HCl; 4-TFMOP hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethoxypiperidine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.