Description

4-Ethoxy-3-(trifluoromethyl)benzonitrile, 97% is a high-purity fluorinated aromatic nitrile building block. This compound is valued for its unique trifluoromethyl and ethoxy substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily sought by R&D and process chemists in the pharmaceutical and agrochemical industries for use in medicinal chemistry, lead optimization, and the synthesis of advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced bioactivity.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, or organic electronic materials due to its aromatic and fluorinated structure.
• Cross-Coupling Reactions: The nitrile and halogen (if present) functionalities make it suitable for Suzuki, Sonogashira, and other palladium-catalyzed coupling reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.

Basic Information

Product Name	4-Ethoxy-3-(Trifluoromethyl)Benzonitrile, 97%
CAS No.	1206593-22-7
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	3-Trifluoromethyl-4-ethoxybenzonitrile; 4-Ethoxy-α,α,α-trifluoro-m-toluonitrile; 4-Cyano-2-ethoxybenzotrifluoride; 2-Ethoxy-α,α,α-trifluoro-p-toluonitrile; 4-Ethoxy-3-trifluoromethylbenzonitrile; 3-Cyano-4-ethoxybenzotrifluoride; m-Toluonitrile, α,α,α-trifluoro-4-ethoxy-
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-3-(trifluoromethyl)benzonitrile, 97% is manufactured under a quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.