Description

tert-Butyl 5-Amino-3,4-Dihydroquinoline-1(2H)-Carboxylate is a high-purity, protected amine derivative of the tetrahydroquinoline scaffold, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive amino group for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring sophisticated heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Process Chemistry: Serves as a starting material or intermediate in the scalable synthesis of active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Synthesis: Employed in the research and development of new pesticides and herbicides that utilize complex nitrogen-containing heterocycles.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or molecular probes to study biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental building block supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 5-Amino-3,4-Dihydroquinoline-1(2H)-Carboxylate
CAS No.	1206248-74-9
Molecular Formula	C14H18N2O2
Molecular Weight	246.31 g/mol
Synonyms	1-Boc-5-amino-1,2,3,4-tetrahydroquinoline; 5-Amino-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; tert-Butyl 5-amino-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1,2,3,4-Tetrahydroquinoline-1-carboxylic acid, 5-amino-, 1,1-dimethylethyl ester; 5-Amino-N-Boc-1,2,3,4-tetrahydroquinoline; Boc-5-amino-THQ; 5-Amino-THQ-Boc
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Amino-3,4-Dihydroquinoline-1(2H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and commercial projects with material suitable for research use and can provide material manufactured under cGMP guidelines for advanced clinical stage applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.