Description

2-(Azetidin-3-Yl)Acetonitrile is a versatile and high-value nitrile-functionalized azetidine building block, essential for advanced organic synthesis. Its unique structure, featuring a strained four-membered azetidine ring, makes it a critical intermediate for constructing complex molecules with targeted biological activity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and kinase inhibitor research.
• Medicinal Chemistry Building Block: Used in scaffold hopping and structure-activity relationship (SAR) studies to introduce the azetidine moiety, which can improve metabolic stability and pharmacokinetic properties.
• Agrochemical Synthesis: Serves as a precursor in the creation of new herbicides and fungicides with novel modes of action.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and molecular probes for target identification and validation in biological systems.
• Ligand Development: Useful for constructing chelating ligands in catalysis and materials science applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the incorporation of a functionalized azetidine ring.

Basic Information

Product Name	2-(Azetidin-3-Yl)Acetonitrile
CAS No.	1205750-84-0
Molecular Formula	C5H8N2
Molecular Weight	96.13 g/mol
Synonyms	3-(Cyanomethyl)azetidine; Azetidin-3-ylacetonitrile; 3-Azetidineacetonitrile; 1-Azetidin-3-ylacetonitrile; (Azetidin-3-yl)acetonitrile; 2-(Azetidin-3-yl)ethanenitrile; 3-(Cyanomethyl)-1-azetidine (base); 1205750-84-0
EINECS	Contact for details

Quality Control

Every batch of 2-(Azetidin-3-Yl)Acetonitrile is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity, and impurity profile is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.