Description

(2R)-2-Amino-3-[3-(Trifluoromethyl)Phenyl]Propan-1-Ol CAS NO 1205542-65-9 is a high-purity chiral amino alcohol building block featuring a trifluoromethylphenyl group, a structural motif prized for its ability to modulate the physicochemical properties of target molecules. This compound is critical for research and development in advanced organic synthesis, particularly where precise stereochemistry and fluorine incorporation are required. It serves as a key intermediate for pharmaceutical chemists and agrochemical researchers developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in constructing advanced herbicide and pesticide molecules where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Peptidomimetics Research: Incorporated into peptide analogs to improve metabolic stability and binding affinity by leveraging the properties of the fluorine atom.
• Material Science: Explored as a building block for specialty polymers and advanced organic materials with unique surface properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.

Basic Information

Product Name	(2R)-2-Amino-3-[3-(Trifluoromethyl)Phenyl]Propan-1-Ol
CAS No.	1205542-65-9
Molecular Formula	C10H12F3NO
Molecular Weight	219.20 g/mol
Synonyms	(R)-2-Amino-3-(3-(trifluoromethyl)phenyl)propan-1-ol; (2R)-2-Amino-3-(α,α,α-trifluoro-m-tolyl)-1-propanol; 3-(3-Trifluoromethylphenyl)-(R)-alaninol; (R)-3-(3-Trifluoromethylphenyl)isoserine alcohol; 1-Propanol, 2-amino-3-[3-(trifluoromethyl)phenyl]-, (2R)-; (R)-2-Amino-3-(3-trifluoromethylphenyl)propan-1-ol; (R)-3-(3-Trifluoromethylphenyl)-2-aminopropan-1-ol
EINECS	Contact for details

Quality Control

Our (2R)-2-Amino-3-[3-(Trifluoromethyl)Phenyl]Propan-1-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.