Description

3-Bromo-5-(Hydroxymethyl)Benzonitrile is a versatile benzonitrile derivative featuring both bromo and hydroxymethyl functional groups, making it a valuable bifunctional building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing active pharmaceutical ingredients (APIs), ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging its halogen and alcohol functionalities.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Monomer: Employed in the synthesis of functional polymers and liquid crystals, where the benzonitrile core contributes to thermal stability and mesomorphic properties.
• Chemical Biology Probe Synthesis: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	3-Bromo-5-(Hydroxymethyl)Benzonitrile
CAS No.	1205515-06-5
Molecular Formula	C8H6BrNO
Molecular Weight	212.05 g/mol
Synonyms	5-(Bromomethyl)-3-hydroxybenzonitrile; 3-Bromo-5-(hydroxymethyl)benzonitrile; 5-Cyano-3-(hydroxymethyl)phenyl bromide; Benzonitrile, 3-bromo-5-(hydroxymethyl)-; 3-Bromo-5-hydroxymethylbenzonitrile; (3-Bromo-5-cyanophenyl)methanol
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(Hydroxymethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment. We adhere to cGMP guidelines where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.