Description

Norsufentanil-D3 CAS NO 1204688-16-3 is a deuterium-labeled analog of the potent synthetic opioid norsufentanil, specifically designed for use as an internal standard in analytical chemistry. This high-purity stable isotope-labeled compound is critical for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily utilized by pharmaceutical research laboratories, forensic toxicology departments, and contract research organizations (CROs) engaged in pharmacokinetic studies, drug metabolism research, and the development of sensitive bioanalytical methods for opioid detection.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference in liquid chromatography-tandem mass spectrometry for the accurate measurement of norsufentanil and related compounds in complex biological matrices.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of sufentanil analogs.
• Forensic Analysis: Essential for the precise identification and quantification of potent synthetic opioids in forensic toxicology screenings and post-mortem investigations.
• Clinical Research: Supports clinical studies monitoring opioid levels in patient plasma or serum for therapeutic drug monitoring or safety profiling.
• Method Development & Validation: A key component in developing, optimizing, and validating robust, regulatory-compliant analytical methods (e.g., following FDA/EMA guidelines).
• Reference Material: Acts as a certified reference material (CRM) for calibrating instruments and ensuring data integrity in GLP/GMP environments.

Basic Information

Product Name	Norsufentanil-D3
CAS No.	1204688-16-3
Molecular Formula	C21H27D3N2O3S
Molecular Weight	393.56 g/mol (deuterated form)
Synonyms	N-Phenyl-N-[4-(methoxymethyl)-1-(2-thienylcarbonyl)-4-piperidinyl]propanamide-d3; Norsufentanil-d3; Deuterated Norsufentanil; Norsufentanil Internal Standard; [2H3]-Norsufentanil; 4-(Methoxymethyl)-1-(2-thiophenecarbonyl)-N-phenyl-N-(propionyl-d3)-4-piperidinecarboxamide; Norsufentanil (phenyl-d3)
EINECS	Contact for details

Quality Control

Every batch of Norsufentanil-D3 is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Our quality commitment includes comprehensive testing via NMR, HPLC, and mass spectrometry to confirm isotopic enrichment, chemical identity, and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data including assay, isotopic purity, and solvent residues, supporting compliance in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with all applicable laboratory safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.