Description

2,3-Difluoro-6-(Benzyloxy)Phenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is a critical building block in modern cross-coupling reactions, enabling the efficient construction of complex fluorinated aromatic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its stability as a pinacol ester makes it a reliable and convenient reagent for demanding synthetic sequences.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used to create novel fluorinated aromatic compounds with potential herbicidal, fungicidal, or insecticidal activity.
• Material Science: Serves as a monomer or building block for developing advanced organic electronic materials, such as OLEDs or semiconductors, where fluorine substitution tunes electronic properties.
• Chemical Synthesis: Employed in academic and industrial R&D labs for constructing complex, multi-substituted biphenyl and heterobiaryl scaffolds.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing specialized fluorinated ligands used in catalysis.

Basic Information

Product Name	2,3-Difluoro-6-(Benzyloxy)Phenylboronic Acid Pinacol Ester
CAS No.	1204580-70-0
Molecular Formula	C19H21BF2O3
Molecular Weight	346.18 g/mol
Synonyms	2,3-Difluoro-6-(benzyloxy)benzeneboronic acid pinacol ester; (2,3-Difluoro-6-(benzyloxy)phenyl)boronic acid pinacol ester; 2-(2,3-Difluoro-6-(benzyloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2,3-Difluoro-6-(benzyloxy)phenylboronic acid, pinacol ester; 6-(Benzyloxy)-2,3-difluorophenylboronic acid pinacol ester; B-[2,3-Difluoro-6-(phenylmethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-6-(Benzyloxy)Phenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive analytical data, including HPLC purity and NMR confirmation of structure. Certificates of Analysis (COA) detailing all specifications are available upon request for every batch shipped.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.