Description

3-(Trifluoromethyl)Pyridin-4-Ylboronic Acid is a high-purity boronic acid derivative, a crucial building block in modern synthetic chemistry. Its value lies in enabling efficient cross-coupling reactions, specifically Suzuki-Miyaura couplings, to construct complex molecules with precision. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing the trifluoromethylpyridine moiety.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that benefit from the stability and lipophilicity of the trifluoromethyl group.
• Material Science: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura reactions to form carbon-carbon bonds, facilitating the construction of biaryl and heterobiaryl structures.
• Chemical Research & Development: A valuable reagent in medicinal chemistry and process chemistry for library synthesis and lead optimization.
• Ligand Precursor: Can be utilized to synthesize novel bidentate or tridentate ligands for catalysis.

Basic Information

Product Name	3-(Trifluoromethyl)Pyridin-4-Ylboronic Acid
CAS No.	1204334-17-7
Molecular Formula	C6H5BF3NO2
Molecular Weight	190.92 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-4-pyridineboronic acid; 3-Trifluoromethylpyridine-4-boronic acid; 4-Borono-3-(trifluoromethyl)pyridine; 3-CF3-4-Pyridylboronic Acid; PINACOL ESTER OF 3-(TRIFLUOROMETHYL)PYRIDIN-4-YLBORONIC ACID (common precursor); [3-(Trifluoromethyl)-4-pyridyl]boronic acid
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)Pyridin-4-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance in sensitive applications like Suzuki coupling. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.