Description

2-(1,1-Difluoroethyl)Naphthalene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and functional materials, where the difluoroethyl group can impart desirable metabolic stability and lipophilicity. It is needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and material science industries seeking to incorporate this unique fluorinated motif into novel molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and environmental persistence.
• Material Science: Acts as a monomer or building block for creating specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Negishi) and as a substrate for further functionalization to create complex, fluorinated molecular architectures.
• Life Science Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and as a probe molecule in biochemical assays.

Basic Information

Product Name	2-(1,1-Difluoroethyl)Naphthalene
CAS No.	1204296-00-3
Molecular Formula	C₁₂H₁₀F₂
Molecular Weight	192.21 g/mol
Synonyms	2-(1,1-Difluoroethyl)naphthalene; 1,1-Difluoro-1-(naphthalen-2-yl)ethane; Naphthalene, 2-(1,1-difluoroethyl)-; 2-(1,1-Difluoroethyl)naphthalene; 2-(α,α-Difluoroethyl)naphthalene; 2-(Difluoroethyl)naphthalene; 2-(1,1-Difluoroethyl)naphthalene (CAS 1204296-00-3)
EINECS	Contact for details

Quality Control

Our 2-(1,1-Difluoroethyl)Naphthalene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC or GC), related substances, and residual solvents are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.