Description

1-Chloro-3-(1,1-Difluoropropyl)Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a chlorophenyl group and a gem-difluoropropyl moiety, enabling precise structural modifications to enhance the physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for introducing lipophilic, metabolically stable difluoroalkyl groups into drug candidates, particularly in kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro group can improve bioavailability and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for high-performance displays.
• Organic Electronics: Employed in the development of novel organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: The chloro substituent makes it a suitable substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of gem-difluoro substitution on aromatic system reactivity and conformation.

Basic Information

Product Name	1-Chloro-3-(1,1-Difluoropropyl)Benzene
CAS No.	1204295-82-8
Molecular Formula	C9H9ClF2
Molecular Weight	190.62 g/mol
Synonyms	3-Chloro-1-(1,1-difluoropropyl)benzene; m-Chloro-(1,1-difluoropropyl)benzene; 1-(3-Chlorophenyl)-1,1-difluoropropane; 3-(1,1-Difluoropropyl)chlorobenzene; Benzene, 1-chloro-3-(1,1-difluoropropyl)-; m-(1,1-Difluoropropyl)chlorobenzene; 1-Chloro-3-(α,α-difluoropropyl)benzene
EINECS	Contact for details

Quality Control

Our production of 1-Chloro-3-(1,1-Difluoropropyl)Benzene adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization using GC, HPLC, NMR, and GC-MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical quality attributes are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0% (Area %)
Purity (HPLC)	≥ 96.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0% Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.