Description

Candesartan Methyl Ester Desethyl Analog is a key pharmaceutical intermediate and reference standard used in the development and quality control of active pharmaceutical ingredients (APIs). This compound is of critical importance for ensuring the purity, efficacy, and regulatory compliance of related drug substances. It is primarily required by research institutions, analytical laboratories, and pharmaceutical manufacturers involved in the synthesis and analysis of sartan-class cardiovascular medications.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthetic pathway for advanced angiotensin II receptor antagonists.
• Analytical Reference Standard: Used for method development, validation, and routine quality control (QC) testing in HPLC, GC, and LC-MS assays.
• Impurity Standard: Serves as a certified reference material (CRM) for identifying and quantifying process-related impurities and degradation products.
• Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic analogs.
• Regulatory Documentation: Provides essential data for Drug Master Files (DMFs), Investigational New Drug (IND) applications, and New Drug Applications (NDAs).
• Metabolite Studies: Used in pharmacokinetic and metabolic pathway research for related pharmaceutical compounds.

Basic Information

Product Name	Candesartan Methyl Ester Desethyl Analog
CAS No.	1203674-06-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Candesartan Desethyl Methyl Ester; Desethyl Candesartan Methyl Ester; 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid Methyl Ester (Desethyl Analog); BIBR 277 Desethyl Methyl Ester; TCV-116 Desethyl Methyl Ester Analog; (Desethyl) Candesartan Cilexetil Methyl Ester Impurity; BPB Impurity E (Methyl Ester)
EINECS	Contact for details

Quality Control

Our Candesartan Methyl Ester Desethyl Analog is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D and quality control. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.