Description

Pyrrolidine, 3-Fluoro-4-Methoxy-, (3R,4R)-Rel- is a high-purity, chiral fluorinated pyrrolidine derivative, a crucial building block in modern organic synthesis. Its value lies in its stereochemically defined structure, which is essential for imparting specific biological activity and metabolic stability to target molecules. This advanced pharmaceutical intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially in central nervous system (CNS) and antiviral research.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorine atom and specific stereochemistry can enhance bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorination and methoxy substitution on pharmacokinetic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	Pyrrolidine, 3-Fluoro-4-Methoxy-, (3R,4R)-Rel-
CAS No.	1203566-98-6
Molecular Formula	C5H10FNO
Molecular Weight	119.14 g/mol
Synonyms	(3R,4R)-3-Fluoro-4-methoxypyrrolidine; rel-(3R,4R)-3-Fluoro-4-methoxypyrrolidine; 3-Fluoro-4-methoxy-(3R,4R)-pyrrolidine; 3-Fluoro-4-methoxy-(R,R)-pyrrolidine; (R,R)-3-Fluoro-4-methoxypyrrolidine; Fluorinated pyrrolidine derivative; Chiral fluorinated pyrrolidine; 4-Methoxy-3-fluoropyrrolidine, (3R,4R)-
EINECS	Contact for details

Quality Control

Our Pyrrolidine, 3-Fluoro-4-Methoxy-, (3R,4R)-Rel- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP standards for advanced pharmaceutical intermediates, ensuring reliable and consistent performance in your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed when not in use to prevent moisture absorption or contamination. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.