Description

2',4'-Difluoro-3'-(Trifluoromethyl) Acetophenone is a high-value fluorinated aromatic ketone building block, distinguished by its unique trifluoromethyl and difluoro substitution pattern. This compound is critical for introducing lipophilicity and metabolic stability into target molecules, making it a sought-after intermediate in advanced synthesis. It is primarily utilized by pharmaceutical and agrochemical R&D departments for the development of novel active ingredients, particularly in the creation of protease inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially protease inhibitors and kinase inhibitors.
• Agrochemical Active Ingredient Development: Used in research for creating new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Material Science Research: Serves as a precursor for fluorinated liquid crystals, polymers, and advanced organic electronic materials.
• Chemical Synthesis Building Block: Employed in cross-coupling reactions, Friedel-Crafts acylation, and as a precursor for heterocyclic compounds.
• R&D for Fluorine Chemistry: Essential for academic and industrial laboratories studying the effects of fluorine substitution on molecular properties.

Basic Information

Product Name	2',4'-Difluoro-3'-(Trifluoromethyl) Acetophenone
CAS No.	1202679-46-6
Molecular Formula	C9H5F5O
Molecular Weight	224.13 g/mol
Synonyms	1-(2,4-Difluoro-3-(trifluoromethyl)phenyl)ethan-1-one; 2',4'-Difluoro-3'-trifluoromethylacetophenone; 2,4-Difluoro-α,α,α-trifluoro-3-acetyltoluene; 3-Acetyl-2,4-difluorobenzotrifluoride; 2,4-Difluoro-3-(trifluoromethyl)acetophenone; 1-[2,4-Difluoro-3-(trifluoromethyl)phenyl]ethanone; Ethanone, 1-[2,4-difluoro-3-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Every batch of 2',4'-Difluoro-3'-(Trifluoromethyl) Acetophenone is produced under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive R&D and scale-up processes. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles via validated methods such as HPLC, GC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.