Description

4-Ethynyl-1,1-Difluorocyclohexane is a versatile fluorinated building block featuring both a strained cyclohexane ring and a reactive ethynyl group. This unique structure makes it a valuable intermediate for the synthesis of complex molecules in advanced research and development. It is particularly sought after by medicinal chemists and material scientists working on novel pharmaceuticals, agrochemicals, and specialty polymers where the introduction of fluorine atoms and alkyne functionality is critical for modulating properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorine-containing drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the difluorocyclohexyl moiety can enhance biological activity, stability, and lipophilicity.
• Material Science: Serves as a monomer or cross-linking agent in the production of advanced polymers, resins, and coatings with tailored thermal, chemical, or surface properties.
• Ligand & Catalyst Development: The alkyne group is utilized in click chemistry and as a handle for constructing complex ligands used in asymmetric catalysis and organometallic chemistry.
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) and for introducing fluorinated motifs into molecular scaffolds in academic and industrial R&D settings.
• Liquid Crystal & Electronic Materials: Potential precursor for fluorinated components in liquid crystal displays (LCDs) and organic electronic materials due to its polarizable structure.

Basic Information

Product Name	4-Ethynyl-1,1-Difluorocyclohexane
CAS No.	1202245-66-6
Molecular Formula	C8H10F2
Molecular Weight	144.16 g/mol
Synonyms	1,1-Difluoro-4-ethynylcyclohexane; 4-Ethynyl-1,1-difluorocyclohexane; 1,1-Difluoro-4-ethynyl-cyclohexane; Cyclohexane, 1,1-difluoro-4-ethynyl-; 4-Ethynyl-1,1-difluoro-cyclohexane
EINECS	Contact for details

Quality Control

Every batch of 4-Ethynyl-1,1-Difluorocyclohexane is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from GC, NMR, and HPLC analyses, is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.