Description

H-α-Me-Lys(Boc)-Oh is a protected amino acid derivative, specifically an N-Boc-protected, α-methylated lysine analog, widely used as a critical building block in peptide synthesis. This compound is essential for introducing non-natural, sterically hindered amino acid residues into peptide chains, which can significantly alter biological activity, stability, and pharmacokinetic properties. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Pharmaceutical Intermediate: A key raw material for synthesizing complex peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetic Design: Used to create modified peptides with enhanced metabolic stability and receptor selectivity by incorporating α-methylated amino acids.
• Chemical Biology Research: Serves as a crucial tool for studying protein-protein interactions and enzyme mechanisms by acting as a substrate or inhibitor analog.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a protected monomer in Fmoc/t-Bu or Boc/Bzl strategies for the sequential assembly of custom peptides.
• Bioconjugation & Labeling: The reactive carboxylic acid and protected amine functionalities allow for site-specific modifications and linker attachments.
• Material Science: Potential use in the synthesis of specialized polyamide or peptide-based polymers with unique structural properties.

Basic Information

Product Name	H-α-Me-Lys(Boc)-Oh
CAS No.	1202003-44-8
Molecular Formula	C₁₃H₂₆N₂O₄
Molecular Weight	274.36 g/mol
Synonyms	Nε-Boc-Nα-methyl-L-lysine; (2S)-2-Methyl-6-{[(2-methylpropan-2-yl)oxy]carbonyl}amino}hexanoic acid; Boc-N-Me-Lys-OH; Boc-Nα-Me-L-Lys-OH; Nα-Methyl-Nε-Boc-L-lysine; N-Boc-N'-methyl-L-lysine; α-Methyl-Nε-Boc-L-lysine
EINECS	Contact for details

Quality Control

Our H-α-Me-Lys(Boc)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification tests. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.