Description

3-Amino-Cyclobutanecarboxylic Acid Hydrochloride is a high-purity, pharmaceutically relevant building block, specifically the hydrochloride salt of a constrained β-amino acid. This compound is valued for its role in medicinal chemistry, enabling the synthesis of novel drug candidates with improved metabolic stability and conformational rigidity. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of peptide mimetics, protease inhibitors, and other bioactive molecules targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptidomimetics & Conformationally Restricted Peptides: Used to incorporate the cyclobutane scaffold into peptide backbones, enhancing metabolic stability and modulating receptor selectivity.
• Protease Inhibitor Development: Serves as a core structure in the design of inhibitors for various enzymes, including kinases and proteases.
• Chemical Biology & Biochemical Research: Employed as a tool compound to study enzyme-substrate interactions and protein folding.
• Ligand Synthesis for Catalysis: Can be utilized to create novel chiral ligands for asymmetric synthesis applications.
• Academic & Industrial R&D: Fundamental building block for exploring new chemical space in drug discovery programs.

Basic Information

Product Name	3-Amino-Cyclobutanecarboxylic Acid Hydrochloride
CAS No.	1201190-01-3
Molecular Formula	C5H10ClNO2
Molecular Weight	151.59 g/mol
Synonyms	3-Aminocyclobutanecarboxylic acid hydrochloride; (1r,3s)-3-Aminocyclobutanecarboxylic acid hydrochloride; (1s,3r)-3-Aminocyclobutanecarboxylic acid hydrochloride; 3-ACBC HCl; cis-3-Aminocyclobutanecarboxylic acid hydrochloride; Cyclobutane-3-amino-1-carboxylic acid hydrochloride; 3-Amino-1-cyclobutanecarboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Amino-Cyclobutanecarboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.