Description

(R)-n-Fmoc-2-(2'-Propynyl)Alanine is a non-natural, chiral amino acid derivative featuring a propargyl side chain and an Fmoc-protected amine, making it a critical building block for advanced peptide synthesis. Its primary value lies in enabling the site-specific introduction of alkyne functional groups into peptide chains, which are essential for subsequent bioorthogonal conjugation reactions like Click chemistry. This compound is indispensable for researchers and manufacturers in pharmaceutical development, proteomics, and chemical biology, particularly for creating peptide-drug conjugates, diagnostic probes, and materials with tailored biological activity.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a specialized Fmoc-protected amino acid for the controlled incorporation of alkyne handles into custom peptide sequences.
• Click Chemistry Conjugation: The alkyne moiety enables efficient, site-specific coupling with azide-containing molecules (e.g., fluorescent dyes, PEG linkers, drugs) via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Peptide-Drug Conjugate (PDC) Development: Serves as a key linker component for attaching cytotoxic payloads to targeting peptides in novel cancer therapeutics.
• Chemical Probe and Diagnostic Agent Synthesis: Used to create labeled peptides for imaging, biomarker detection, and studying protein-protein interactions.
• Materials Science and Bioconjugation: Facilitates the functionalization of surfaces, polymers, and nanoparticles with bioactive peptides.
• Academic and Industrial R&D: A vital reagent for exploring new methodologies in peptide chemistry and developing novel bioconjugation platforms.

Basic Information

Product Name	(R)-n-Fmoc-2-(2'-Propynyl)Alanine
CAS No.	1198791-65-9
Molecular Formula	C₂₁H₁₉NO₄
Molecular Weight	349.38 g/mol
Synonyms	Fmoc-(R)-2-(2-Propynyl)alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-pentynoic acid; (R)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(prop-2-yn-1-yl)alanine; Fmoc-D-2-(2'-Propynyl)Ala-OH; Fmoc-D-Propargylalanine; (R)-N-Fmoc-2-(Prop-2-ynyl)alanine; (2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)pent-4-ynoic acid
EINECS	Contact for details

Quality Control

Our (R)-n-Fmoc-2-(2'-Propynyl)Alanine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for chiral purity and chemical assay, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards, and custom synthesis to meet specific pharmaceutical or GMP-grade requirements is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.