Description

(S)-2-(2'-(Diphenylphosphanyl)-[1,1'-Biphenyl]-2-Yl)-4-Phenyl-4,5-Dihydrooxazole is a high-value, chiral phosphine-oxazoline (PHOX) ligand, a cornerstone in modern asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, crucial for synthesizing single-isomer pharmaceutical intermediates and fine chemicals. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of olefins, ketones, and imines, critical for producing chiral active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Catalyzes key reactions like Heck, Suzuki-Miyaura, and allylic alkylation with high enantiomeric excess (ee).
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of chiral drugs, including β-blockers, antivirals, and anti-inflammatory agents.
• Agrochemical Manufacturing: Enables the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A vital tool for methodology development in organic synthesis and catalysis research.
• Fine Chemical Production: For the synthesis of complex, high-value fragrance and flavor compounds requiring specific chirality.

Basic Information

Product Name	(S)-2-(2'-(Diphenylphosphanyl)-[1,1'-Biphenyl]-2-Yl)-4-Phenyl-4,5-Dihydrooxazole
CAS No.	1198791-45-5
Molecular Formula	C33H26NOP
Molecular Weight	483.54 g/mol
Synonyms	(S)-PHOX Ligand; (S)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-4,5-dihydrooxazole; (S)-2-[2-(Diphenylphosphanyl)phenyl]-4,5-dihydro-4-phenyloxazole; (S)-2-(2-Diphenylphosphanylphenyl)-4-phenyl-4,5-dihydrooxazole; (S)-2-(2-Diphenylphosphinophenyl)-4-phenyl-2-oxazoline; (S)-PHOX; (S)-2-(2'-Diphenylphosphanyl-[1,1'-biphenyl]-2-yl)-4-phenyl-4,5-dihydrooxazole
EINECS	Contact for details

Quality Control

Our (S)-PHOX ligand is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including chiral purity verification by HPLC. A Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with every shipment, supporting cGMP and ISO 9001 compliant workflows.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and ensure long-term stability. Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.