Description

Formoterol-D3 is a deuterium-labeled analog of the long-acting β2-adrenergic receptor agonist formoterol, serving as a critical internal standard for precise quantitative analysis. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in bioanalytical and pharmacokinetic studies, where it compensates for matrix effects and instrumental variability. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in method development, drug metabolism studies, and clinical trial support.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) assays for formoterol and its metabolites.
• Bioanalytical Method Development: Critical for developing and validating sensitive and accurate analytical methods for formoterol in biological matrices (e.g., plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Studies: Facilitates the identification and quantification of metabolite profiles using stable isotope dilution techniques.
• Clinical Trial Analysis: Supports the reliable measurement of formoterol concentrations in samples from human clinical trials, ensuring data integrity.
• Quality Control in Manufacturing: Can be employed in analytical QC laboratories for specialized testing of formoterol-based pharmaceutical products.

Basic Information

Product Name	Formoterol-D3
CAS No.	1198353-13-7
Molecular Formula	C19H21D3N2O4
Molecular Weight	347.42 g/mol
Synonyms	Formoterol-d3; (R*,R*)-(±)-Formoterol-d3; 2-Hydroxy-5-[(1RS)-1-hydroxy-2-[[(1RS)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]formanilide-d3; (±)-Formoterol-d3; Araformoterol-d3; Atock-d3; Foradil-d3; Oxeze-d3
EINECS	Contact for details

Quality Control

Our Formoterol-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity, MS for isotopic enrichment verification, and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic purity, residual solvents, and other critical parameters to ensure compliance with your research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.