Description

n-Boc-4-(2-Bromophenyl)Piperidine is a high-purity, protected piperidine derivative that serves as a critical advanced intermediate in modern organic synthesis. Its value lies in the strategic combination of a bromoaryl group and a Boc-protected amine, enabling precise, multi-step construction of complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, especially in the development of central nervous system (CNS) agents, kinase inhibitors, and other bioactive molecules.
• Agrochemical Research: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging its halogenated aromatic structure for bioactivity.
• Chemical Synthesis Scaffold: Serves as a versatile precursor for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) or deprotection to access primary amines.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Academic and R&D Laboratories: A valuable reagent for methodological studies and the exploration of new synthetic pathways in organic chemistry.
• Custom Synthesis Projects: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific, multi-step synthesis projects requiring high-purity intermediates.

Basic Information

Product Name	n-Boc-4-(2-Bromophenyl)Piperidine
CAS No.	1198283-93-0
Molecular Formula	C16H22BrNO2
Molecular Weight	340.26 g/mol
Synonyms	1-Boc-4-(2-Bromophenyl)Piperidine; tert-Butyl 4-(2-Bromophenyl)Piperidine-1-Carboxylate; 4-(2-Bromophenyl)-1-(tert-Butoxycarbonyl)Piperidine; 1-(tert-Butoxycarbonyl)-4-(2-Bromophenyl)Piperidine; 4-(2-Bromophenyl)Piperidine-1-Carboxylic Acid tert-Butyl Ester; N-Boc-4-(o-Bromophenyl)Piperidine; 4-(2-Bromophenyl)-N-Boc-Piperidine; 1-Boc-4-(2-Bromo-Phenyl)-Piperidine
EINECS	Contact for details

Quality Control

Our n-Boc-4-(2-Bromophenyl)Piperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and production needs with material suitable for research use and can discuss custom synthesis to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.