Description

3-Cyclobutoxy-Benzonitrile is a versatile aromatic nitrile derivative featuring a cyclobutyl ether linkage. This compound serves as a valuable advanced pharmaceutical intermediate and a key building block in organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitor and CNS-active molecule libraries.
• Agrochemical Synthesis: Used as a precursor for constructing herbicidal and fungicidal compounds with specific bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of monomers for advanced polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probes: Utilized as a core structure for developing fluorescent tags or activity-based probes for biological target identification.
• Custom Synthesis and Contract Manufacturing: A critical building block supplied to CDMOs for the scale-up and production of client-specific molecules.

Basic Information

Item	Details
Product Name	3-Cyclobutoxy-Benzonitrile
CAS No.	1198223-02-7
Molecular Formula	C11H11NO
Molecular Weight	173.21 g/mol
Synonyms	3-Cyclobutoxybenzonitrile; Benzonitrile, 3-cyclobutoxy-; m-Cyclobutoxybenzonitrile; 3-Cyclobutyloxybenzonitrile; (3-Cyanophenyl) cyclobutyl ether; Cyclobutyl 3-cyanophenyl ether; CAS 1198223-02-7
EINECS	Contact for details

Quality Control

Our 3-Cyclobutoxy-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. For cGMP or other specific regulatory requirements, please contact our technical sales team to discuss available custom synthesis and documentation protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.