Description

2-Cyano-3-(Trifluoromethyl)Phenylboronic Acid is a specialized organoboron compound featuring a cyano group and a trifluoromethyl substituent on the phenyl ring. This unique structure makes it a valuable high-purity building block for advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the cyano and trifluoromethyl groups contribute to biological activity.
• Material Science Research: Serves as a precursor for creating functional organic materials, such as organic light-emitting diodes (OLEDs) and liquid crystals, due to its electron-withdrawing properties.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and enzyme inhibitors for target identification and validation studies.
• Catalyst Ligand Development: Potential use in the design of novel ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	2-Cyano-3-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1198181-40-6
Molecular Formula	C8H5BF3NO2
Molecular Weight	214.94 g/mol
Synonyms	[2-Cyano-3-(trifluoromethyl)phenyl]boronic acid; 2-Cyanotrifluoromethylphenylboronic Acid; (2-Cyano-3-(trifluoromethyl)phenyl)boronic acid; Boronic acid, B-[2-cyano-3-(trifluoromethyl)phenyl]-; 2-CN-3-CF3-PhB(OH)2; 2-Cyano-3-trifluoromethylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 2-Cyano-3-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and production needs with material suitable for research and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.