Description

1-Bromo-2-(Difluoromethyl)-4-Fluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoromethyl and fluorine groups enhance bioavailability and stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create biaryl and complex aromatic systems.
• Fluorine Chemistry Research: An essential reagent for studying the effects of fluorine and difluoromethyl groups on molecular conformation, lipophilicity, and metabolic stability in medicinal chemistry.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized fluorinated dyes and pigments that require specific light-fastness and chemical resistance properties.

Basic Information

Product Name	1-Bromo-2-(Difluoromethyl)-4-Fluorobenzene
CAS No.	1198171-18-4
Molecular Formula	C7H4BrF3
Molecular Weight	225.01 g/mol
Synonyms	2-Bromo-α,α-difluoro-5-fluorotoluene; 4-Fluoro-2-(difluoromethyl)bromobenzene; 1-Bromo-2-(difluoromethyl)-4-fluorobenzene; 2-(Difluoromethyl)-4-fluorobromobenzene; Benzene, 1-bromo-2-(difluoromethyl)-4-fluoro-; 5-Fluoro-2-(difluoromethyl)bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(Difluoromethyl)-4-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and stored away from strong bases and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.