Description

Propargyl-Peg6-Amine CAS NO 1198080-04-4 is a heterobifunctional polyethylene glycol (PEG) linker featuring a propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry and a primary amine for standard amine-reactive conjugations. This compound is essential for creating stable, well-defined bioconjugates and functionalized materials with precise control over architecture and spacing. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced materials science for applications such as ADC development, hydrogel formation, and surface functionalization.

Application

• Bioconjugation and ADC Development: Used as a key linker to attach cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides via its orthogonal click chemistry and amine-reactive handles.
• PEGylation Reagent: Serves as a heterobifunctional PEG spacer to modify biomolecules, enhancing solubility, stability, and pharmacokinetic properties while introducing a clickable site for further functionalization.
• Polymer and Materials Science: Employed in the synthesis of functional polymers, dendrimers, and smart hydrogels where controlled cross-linking and introduction of specific functional groups are required.
• Surface Functionalization: Facilitates the covalent attachment of biomolecules or other entities to surfaces (e.g., nanoparticles, chips, beads) through amine coupling, leaving a propargyl group available for subsequent click chemistry modifications.
• Diagnostic Probe Synthesis: Utilized to build diagnostic imaging agents by linking targeting moieties to reporter molecules (e.g., radionuclide chelators, dyes).
• Chemical Biology Tool: Acts as a versatile reagent for labeling biomolecules in live cells or complex mixtures for pull-down assays, proteomics, and activity-based protein profiling.

Basic Information

Product Name	Propargyl-Peg6-Amine
CAS No.	1198080-04-4
Molecular Formula	C₂₀H₃₉NO₇
Molecular Weight	405.53 g/mol
Synonyms	Propargyl-PEG6-amine; 2,5,8,11,14,17-Hexaoxanonadec-19-yn-1-amine; Propargyl-O-(CH₂CH₂O)₆-CH₂CH₂NH₂; 19-Amino-2,5,8,11,14,17-hexaoxanonadec-19-yne; Amine-PEG6-propargyl; Propargyl-PEG6-NH₂; N-(Propargyl)-3,6,9,12,15,18-hexaoxahenicosan-21-amine; Propargyl hexaethylene glycol amine
EINECS	Contact for details

Quality Control

Our Propargyl-Peg6-Amine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurity profiles. We adhere to cGMP principles where applicable to support our clients in pharmaceutical and diagnostic development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This compound is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Amine Content (Titration)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.