Description

tert-Butyl 4-(Cyclobutanecarbonylamino)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of novel bioactive molecules, particularly in the creation of protease inhibitors and other therapeutic agents targeting the central nervous system. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the production of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those with piperidine-based scaffolds.
• Protease Inhibitor Development: Used in research and production of inhibitors targeting various proteases, which are relevant for treating viral infections and certain cancers.
• CNS-Active Compound Synthesis: Serves as a building block for molecules designed to cross the blood-brain barrier for neurological and psychiatric applications.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific novel chemical entities.
• Academic & Industrial Research: Used in exploratory research for developing new synthetic methodologies and investigating new therapeutic pathways.

Basic Information

Product Name	tert-Butyl 4-(Cyclobutanecarbonylamino)Piperidine-1-Carboxylate
CAS No.	1197980-74-7
Molecular Formula	C15H26N2O3
Molecular Weight	282.38 g/mol
Synonyms	1-Boc-4-(cyclobutanecarboxamido)piperidine; tert-Butyl 4-(cyclobutanecarboxamido)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(cyclobutanecarbonylamino)piperidine; 4-(Cyclobutanecarbonylamino)-1-Boc-piperidine; N-(1-Boc-4-piperidinyl)cyclobutanecarboxamide; Boc-4-(cyclobutanecarboxamido)piperidine; 1-N-Boc-4-N'-cyclobutanoylpiperazine (common misnomer, related structure); 1197980-74-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Cyclobutanecarbonylamino)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) intermediate applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as confirmed by HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.