Description

4-Fluoro-2-Azabicyclo[2.1.1]Hexane-1-Carboxylic Acid is a high-value, fluorinated bicyclic amino acid derivative, serving as a critical building block in modern synthetic chemistry. Its unique constrained scaffold and fluorine atom make it an essential intermediate for developing novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. This compound is primarily targeted at research and development teams in the pharmaceutical industry, particularly those focused on medicinal chemistry, drug discovery, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce conformational rigidity and fluorine-based bioisosteres.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for targeted protein degradation therapeutics.
• Peptidomimetics: Incorporated into peptide analogs to enhance stability against enzymatic degradation and improve membrane permeability.
• Agrochemical Research: Utilized in the discovery and synthesis of new generation herbicides and pesticides with improved efficacy.
• Chemical Biology Probes: Acts as a scaffold for developing molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	4-Fluoro-2-Azabicyclo[2.1.1]Hexane-1-Carboxylic Acid
CAS No.	1196976-68-7
Molecular Formula	C7H8FNO2
Molecular Weight	157.14 g/mol
Synonyms	4-Fluoro-2-azabicyclo[2.1.1]hexane-1-carboxylic acid; 1-Carboxy-4-fluoro-2-azabicyclo[2.1.1]hexane; 4-Fluoro-2-azabicyclo[2.1.1]hexane-1-carboxylic acid, 9CI; 4-Fluoro-1-azabicyclo[2.1.1]hexane-2-carboxylic acid (tautomer); 4-Fluoro-2-azabicyclo[2.1.1]hexane carboxylic acid; Fluorinated bicyclic proline analog; 4-F-Aze(2.1.1)-OH
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Azabicyclo[2.1.1]Hexane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.