Description

2-Trifluoromethylmorpholine is a high-value fluorinated heterocyclic building block of significant interest in advanced chemical synthesis. This compound matters for its ability to introduce the metabolically stable and lipophilic trifluoromethyl group into morpholine-based scaffolds, a key strategy in modern medicinal chemistry. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active ingredients, particularly for agrochemicals and life science applications. 2-Trifluoromethylmorpholine CAS NO 1196532-95-2 offers a critical structural motif for modulating the physicochemical properties of target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for specialized ligands in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with unique surface properties.
• Chemical Biology Probes: Useful for incorporating fluorine tags into molecules for studies using techniques like 19F NMR spectroscopy.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis projects requiring fluorinated morpholine derivatives.

Basic Information

Product Name	2-Trifluoromethylmorpholine
CAS No.	1196532-95-2
Molecular Formula	C5H8F3NO
Molecular Weight	155.12 g/mol
Synonyms	Morpholine, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)morpholine; 2-Trifluoromethyl-morpholine; 4-Trifluoromethylmorpholine (isomer); TFMM; Trifluoromethylmorpholine; 2-TFM; 2-CF3-Morpholine
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethylmorpholine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, and we support our partners with the documentation required for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its fluoride content, ensure containers are properly sealed and stored on secondary containment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Density	~1.3 g/cm³ (at 20°C)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.