Description

4-Methoxy-2-(Trifluoromethoxy)Phenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative, serving as a crucial protected intermediate in modern cross-coupling chemistry. Its core value lies in providing enhanced stability and handling characteristics compared to the free boronic acid, while maintaining high reactivity in Suzuki-Miyaura and other palladium-catalyzed coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for constructing complex molecules containing the 4-methoxy-2-(trifluoromethoxy)phenyl moiety.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring the trifluoromethoxy-substituted aromatic scaffold.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the specific substitution pattern influences bioactivity.
• Material Science: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, via cross-coupling to form conjugated systems.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands or metal-organic frameworks (MOFs) with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and biomarkers for diagnostic and research applications.
• Custom Synthesis and Contract Manufacturing: A critical reagent for fine chemical and custom synthesis houses producing bespoke compounds for client projects.

Basic Information

Product Name	4-Methoxy-2-(Trifluoromethoxy)Phenylboronic Acid, Pinacol Ester
CAS No.	1196395-85-3
Molecular Formula	C14H18BF3O4
Molecular Weight	318.10 g/mol
Synonyms	2-(Trifluoromethoxy)-4-methoxyphenylboronic acid pinacol ester; 4-Methoxy-2-(trifluoromethoxy)benzeneboronic acid pinacol ester; [4-Methoxy-2-(trifluoromethoxy)phenyl]boronic acid pinacol ester; Pinacol [4-Methoxy-2-(trifluoromethoxy)phenyl]boronate; 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl trifluoromethyl ether; B-[4-Methoxy-2-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1196395-85-3
EINECS	Contact for details

Quality Control

Our 4-Methoxy-2-(Trifluoromethoxy)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards required for cGMP and ISO-guided production environments for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.