Description

Sulfamethoxazole-13C6 is a stable isotope-labeled analog of the widely used antibiotic sulfamethoxazole, where six carbon atoms are replaced with the 13C isotope. This compound is an essential internal standard for the precise and accurate quantification of sulfamethoxazole in complex matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in drug metabolism studies, pharmacokinetic research, and residue analysis. The use of this isotopically labeled standard is critical for ensuring data integrity and meeting stringent regulatory requirements in bioanalytical method development and validation.

Application

• Bioanalytical Method Development & Validation: Serves as a critical internal standard for liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays to quantify sulfamethoxazole in biological fluids (plasma, serum, urine).
• Pharmacokinetic and Drug Metabolism Studies (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Veterinary Drug Residue Analysis: Used in food safety testing to monitor and quantify sulfamethoxazole residues in meat, milk, and other animal products.
• Environmental Monitoring: Applied in the analysis of pharmaceutical pollutants in water and soil samples to assess environmental impact.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for sulfamethoxazole-containing drug formulations.
• Forensic Toxicology: Aids in the precise identification and quantification of sulfamethoxazole in forensic investigations.

Basic Information

Product Name	Sulfamethoxazole-13C6
CAS No.	1196157-90-0
Molecular Formula	C1413C6H14N4O3S
Molecular Weight	~ 269.3 g/mol (for 13C6 labeled form)
Synonyms	4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide-13C6; SMZ-13C6; Sulfamethoxazole (13C6); 13C6-Sulfamethoxazole; 13C6-SMX; N1-(5-Methyl-3-isoxazolyl)sulfanilamide-13C6; 4-Amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide-13C6; Isotopically Labeled Sulfamethoxazole
EINECS	Contact for details

Quality Control

Our Sulfamethoxazole-13C6 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized using NMR, HPLC, and mass spectrometry to confirm isotopic enrichment and chemical identity. Certificates of Analysis (COA) are provided, detailing specifications for isotopic purity, chemical purity, and residual solvents. We adhere to relevant industry standards to support our clients' compliance with GLP and GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C6)	≥ 99 atom % 13C
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.