Description

4-Ethynyl-2-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block featuring both an ethynyl group and a trifluoromethyl substituent. This unique structure makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the pyridine and trifluoromethyl motifs.
• Ligand Synthesis: Serves as a precursor for creating sophisticated ligands in catalysis and coordination chemistry, useful in cross-coupling and other transition metal-catalyzed reactions.
• Material Science: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system.
• Chemical Biology: Utilized as a probe or tag in bio-conjugation and click chemistry applications, taking advantage of the reactive alkyne functionality.
• Fluorinated Compound Library: A valuable scaffold for constructing diverse fluorinated compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	4-Ethynyl-2-(Trifluoromethyl)Pyridine
CAS No.	1196151-89-9
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	2-(Trifluoromethyl)-4-ethynylpyridine; 4-Ethynyl-2-(trifluoromethyl)pyridine; 4-Ethynyl-α,α,α-trifluoro-2-picoline; 2-Trifluoromethyl-4-ethynylpyridine; 4-Ethynyl-2-trifluoromethylpyridine; Pyridine, 4-ethynyl-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-2-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.