Description

n-Boc-3-Amino-2,2-Difluoropropionic Acid is a high-purity, protected amino acid derivative featuring a tert-butoxycarbonyl (Boc) group and a difluoromethyl moiety. This compound is a critical building block in modern organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules where its unique fluorine substitution pattern can enhance metabolic stability and binding affinity. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for peptide mimetics, protease inhibitors, and other complex target syntheses.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated peptide analogs and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in constructing scaffolds for inhibitors targeting various enzymes like HCV NS3/4A protease.
• Peptidomimetics: Incorporation into non-peptide structures to mimic peptide function with improved pharmacokinetic properties.
• Agrochemical Research: Serves as a building block for novel fluorinated herbicides and pesticides.
• Chemical Biology Probes: Useful for creating fluorinated analogs to study protein-ligand interactions and metabolic pathways.
• Material Science: Potential monomer for specialty polymers where fluorine content imparts specific chemical resistance or surface properties.

Basic Information

Product Name	n-Boc-3-Amino-2,2-Difluoropropionic Acid
CAS No.	1196145-07-9
Molecular Formula	C8H13F2NO4
Molecular Weight	225.19 g/mol
Synonyms	3-[(tert-Butoxycarbonyl)amino]-2,2-difluoropropanoic Acid; 2,2-Difluoro-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic Acid; Boc-Aad(2F)-OH; (3-((tert-Butoxycarbonyl)amino)-2,2-difluoropropanoic Acid); N-Boc-3-amino-2,2-difluoropropionic acid; tert-Butyl (3-carboxy-2,2-difluoropropyl)carbamate; 2,2-Difluoro-3-{[(2-methyl-2-propanyl)oxy]carbonylamino}propanoic Acid
EINECS	Contact for details

Quality Control

Our n-Boc-3-Amino-2,2-Difluoropropionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.