Description

5-Chloro-2-(Trifluoromethyl)Phenylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters for its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily needed by pharmaceutical R&D teams, agrochemical manufacturers, and advanced material scientists for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and chloro-substituted biphenyl scaffolds.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides where the specific halogenated aryl motif imparts desired biological activity and stability.
• Material Science Research: Serves as a monomer or building block for creating advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and as a core structure in metal-organic frameworks (MOFs).
• Chemical Biology & Probe Synthesis: Utilized for labeling and modifying biomolecules or creating molecular probes for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1195945-67-5
Molecular Formula	C7H5BClF3O2
Molecular Weight	223.38 g/mol
Synonyms	[5-Chloro-2-(trifluoromethyl)phenyl]boronic acid; (5-Chloro-2-(trifluoromethyl)phenyl)boronic acid; 2-Trifluoromethyl-5-chlorophenylboronic acid; Boronic acid, B-[5-chloro-2-(trifluoromethyl)phenyl]-; 5-Chloro-α,α,α-trifluoro-o-tolylboronic acid; 5-Chloro-2-trifluoromethylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support cGMP and ISO 9001 compliant production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.