Description

H-L-Glu-Nh2·Hcl CAS NO 1195209-18-7 is a high-purity, protected amino acid derivative, specifically the hydrochloride salt of H-L-Glutamine amide. This compound is a critical building block in peptide synthesis and pharmaceutical research, offering precise control over molecular structure. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in advanced organic synthesis and drug discovery programs.

Application

• Peptide Synthesis: Serves as a key protected glutamine residue for the solid-phase and solution-phase synthesis of complex peptides and proteins.
• Pharmaceutical Intermediates: Used in the research and development of novel active pharmaceutical ingredients (APIs) and therapeutic compounds.
• Biochemical Research: Employed as a substrate or precursor in enzymatic studies and metabolic pathway investigations.
• Protecting Group Chemistry: The amide and HCl salt functionalities make it a valuable intermediate in multi-step synthetic routes requiring selective deprotection.
• Combinatorial Chemistry: Utilized in the generation of diverse chemical libraries for high-throughput screening in drug discovery.

Basic Information

Item	Details
Product Name	H-L-Glu-Nh2·Hcl
CAS No.	1195209-18-7
Molecular Formula	C5H11N3O3·HCl
Molecular Weight	197.62 g/mol (Free base: 161.16 g/mol)
Synonyms	H-Gln-NH2·HCl; L-Glutamine amide hydrochloride; (S)-2-Amino-4-carbamoylbutanoic acid hydrochloride; Fmoc-Gln(Trt)-OH precursor; Glutamine amide HCl salt; Protected glutamine derivative; 2-Aminoglutaramic acid hydrochloride
EINECS	Contact for details

Quality Control

Our H-L-Glu-Nh2·Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric purity, and identity confirmation (IR, NMR). We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.