Description

tert-Butyl 3-Cyano-3-Hydroxypyrrolidine-1-Carboxylate is a high-value, multifunctional chiral building block and synthetic intermediate. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals due to its versatile pyrrolidine scaffold bearing both cyano and hydroxyl functional groups. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of drug candidates, particularly for central nervous system (CNS) agents, enzyme inhibitors, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioactive Molecules: The pyrrolidine core is integral to designing peptidomimetics and other bioactive molecules that mimic natural peptides.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological processes and target identification.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs/CMOs) serving the life sciences sector.

Basic Information

Product Name	tert-Butyl 3-Cyano-3-Hydroxypyrrolidine-1-Carboxylate
CAS No.	1194376-31-2
Molecular Formula	C10H16N2O3
Molecular Weight	212.25 g/mol
Synonyms	1-Boc-3-cyano-3-hydroxypyrrolidine; 3-Hydroxy-3-cyanopyrrolidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-hydroxy-3-cyanopyrrolidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-cyano-3-hydroxypyrrolidine; 3-Cyano-3-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester; Boc-3-cyano-3-hydroxypyrrolidine; (3R/S)-1-Boc-3-cyano-3-hydroxypyrrolidine (racemic mixture)
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Cyano-3-Hydroxypyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.