Description

2-Bromo-3',5'-Difluoro-2'-Hydroxyacetophenone, also known as 2-Bromo-1-(3,5-Difluoro-2-Hydroxyphenyl)Ethan-1-One or 2-(Bromoacetyl)-4,6-Difluorophenol, is a specialized halogenated acetophenone derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromoacetyl and difluorophenol moieties, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and pesticides with enhanced efficacy and selectivity.
• Material Science Research: Used in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its halogen and fluorine substituents.
• Chemical Biology Probes: Serves as a reactive handle for labeling and modifying biomolecules in proteomics and diagnostic assay development.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) for constructing biaryl and complex aromatic systems.
• Fluorine Chemistry: Essential intermediate for introducing difluorophenol motifs into target molecules, leveraging the unique properties of fluorine atoms.

Basic Information

Item	Details
Product Name	2-Bromo-3',5'-Difluoro-2'-Hydroxyacetophenone
CAS No.	1192815-24-9
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	2-Bromo-1-(3,5-Difluoro-2-Hydroxyphenyl)Ethan-1-One; 2-(Bromoacetyl)-4,6-Difluorophenol; 1-(3,5-Difluoro-2-Hydroxyphenyl)-2-Bromoethanone; 2-Bromo-1-(3,5-difluoro-2-hydroxyphenyl)ethanone; 4,6-Difluoro-2-(bromoacetyl)phenol; α-Bromo-3,5-difluoro-2-hydroxyacetophenone; 2-Bromo-2'-hydroxy-3',5'-difluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2-Bromo-3',5'-Difluoro-2'-Hydroxyacetophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity, potency, and impurity profiles. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring the material is suitable for research and development as well as scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed when not in use to prevent moisture absorption and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.