Description

2-(2-Fluoro-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1192548-08-5 is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound serves as a critical intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, a common scaffold in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly those containing fluorinated and methylated aromatic systems.
• Agrochemical Synthesis: Employed in creating advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic motifs.
• Material Science Research: Acts as a precursor for organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Probe Development: Useful for incorporating boronate handles into molecules for sensing, labeling, and protein interaction studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of tailored, high-value intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	2-(2-Fluoro-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1192548-08-5
Molecular Formula	C13H18BFO2
Molecular Weight	236.09 g/mol
Synonyms	2-Fluoro-3-methylbenzeneboronic acid pinacol ester; (2-Fluoro-3-methylphenyl)boronic acid pinacol ester; 2-(2-Fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2-fluoro-3-methylphenyl)boronate; 2-Fluoro-3-methylphenylboronic acid pinacol ester; B-(2-Fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(2-Fluoro-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and lot-to-lot consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.