Description

2-[2-Fluoro-5-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aryl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl and fluoro substituents impart desired biological activity and environmental persistence profiles.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: An indispensable reagent in medicinal chemistry and process chemistry for constructing complex, fluorinated biaryl systems via palladium-catalyzed cross-coupling.
• Diagnostic Reagent Manufacturing: Potential use in synthesizing fluorescent probes or molecular tags used in bioimaging and diagnostic assays.

Basic Information

Product Name	2-[2-Fluoro-5-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1192045-31-0
Molecular Formula	C13H15BF4O2
Molecular Weight	290.07 g/mol
Synonyms	2-Fluoro-5-(trifluoromethyl)phenylboronic acid pinacol ester; (2-Fluoro-5-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-Fluoro-α,α,α-trifluoro-p-tolylboronic acid pinacol ester; 2-(2-Fluoro-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Fluoro-5-trifluoromethylbenzeneboronic acid pinacol ester; 5-Trifluoromethyl-2-fluorophenylboronic acid pinacol ester; CAS 1192045-31-0
EINECS	Contact for details

Quality Control

Our 2-[2-Fluoro-5-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.