Description

2,6-Difluoro-Phenylalanine Ethyl Ester is a fluorinated amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. This compound is valued for its ability to introduce both fluorine atoms and a protected amino acid functionality into target molecules, enabling the fine-tuning of physicochemical properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated phenylalanine analogs, enhancing metabolic stability and lipophilicity of peptide drugs.
• Agrochemical Synthesis: Serves as a precursor in creating novel fluorinated pesticides and herbicides, where fluorine atoms can improve bioavailability and environmental persistence.
• Chemical Biology Probes: Employed in the design of fluorinated amino acid tags and probes for studying protein structure, function, and interactions.
• Material Science Research: Investigated as a monomer or building block for specialty polymers and advanced materials with unique electronic or surface properties.

Basic Information

Product Name	2,6-Difluoro-Phenylalanine Ethyl Ester
CAS No.	1192001-75-4
Molecular Formula	C₁₁H₁₃F₂NO₂
Molecular Weight	229.22 g/mol
Synonyms	Ethyl 2-amino-3-(2,6-difluorophenyl)propanoate; (S)-2-Amino-3-(2,6-difluorophenyl)propanoic acid ethyl ester; 2,6-Difluoro-DL-phenylalanine ethyl ester; DL-2,6-Difluorophenylalanine ethyl ester; F2Phe-OEt; 2,6-DFPA-OEt; Ethyl 3-(2,6-difluorophenyl)-2-aminopropanoate
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-Phenylalanine Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% ee (for enantiomerically pure grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.